1. In 1599, Shakespeare joined the Lord Chamberlain's Men, a leading acting troupe in London. This marked a significant milestone in his career as he became a shareholder and principal playwright for the company. The Lord Chamberlain's Men later became known as the King's Men after the accession of King James I in 1603.
2. In 1608, Shakespeare's play "Pericles, Prince of Tyre" was published, marking the first time one of his plays was printed in quarto. This publication is significant because it brought Shakespeare's work to a wider audience beyond those who had seen his plays performed on stage.