What event is foreshadowed by aside in William Macbeth Act I Scene IV?

In Act I, Scene IV of William Shakespeare's play Macbeth, the aside spoken by Lady Macbeth foreshadows the regicide, or killing of King Duncan. Lady Macbeth expresses her determination to manipulate and goad Macbeth into committing the murder, saying:

"Hie thee hither,

That I may pour my spirits in thine ear,

And chastise with the valor of my tongue

All that impedes thee from the golden round,

Which fate and metaphysical aid doth seem

To have thee crowned withal."

Here, Lady Macbeth directly suggests that Macbeth will become king, and she plans to use her influence and persuasiveness to ensure it happens. This aside foreshadows the regicide that takes place later in the play, setting in motion the tragic events that follow.