- Establishing indigo as a major cash crop in the American colonies.
- Developing methods to process and dye indigo for commercial use.
- Becoming a successful businesswoman and plantation owner.
- Raising funds and supplies for the American Revolutionary War.
- Serving as the First Lady of South Carolina from 1792 to 1796.
- Supporting the education of women.
- Establishing the first free school in South Carolina.
- Writing a book on the cultivation and processing of indigo, which was published posthumously.