Movies:
* El bien de los niños (2006) - as María
* La teta asustada (2009) - as "La Teta Asustada"
* Django sin cadenas (2012) - as Broomhilda von Shaft (as "Melania Urbina")
* Magallanes (2015) - as Patricia
* Rosa (2016) - as Rosa
* El futuro ya fue (2017) - as Mrs. Sánchez
* The Green Inferno (2013) - as Karina
* The Chaperone (2011) - as Natalia
* The Burning Season (2014) - as Carmen
* The Last Exorcism Part II (2013) - as Isabella
* The Sacrament (2013) - as Sister Anna
* The Pyramid (2014) - as Fiona
Television:
* Asuntos privados (2003-2004) - as Teresa
* Torbellino (2006) - as Marisol
* Los exitosos Pells (2008-2009) - as Claudia
* Los exitosos Pérez (2009-2010) - as Claudia
* Lalola (2007-2009) - as Laura
* Amas (2010) - as María
* Los simuladores (2002-2003) - as Laura
* The Killing (2011-2012) - as Detective Linden
* Breaking Bad (2010-2013) - as Jane Margolis
* The Walking Dead (2010-2018) - as Carol Peletier
* The Leftovers (2014-2017) - as Nora Durst
* The Handmaid's Tale (2017-present) - as June Osborne
This is not an exhaustive list, but it represents some of her most prominent work. Melania Urbina is a versatile actress with a wide range of roles to her credit.