Who are a comedy couple from the 1950s and 60s that were married in real life have two sons?

You're likely thinking of Lucille Ball and Desi Arnaz.

They were a hugely popular comedy duo in the 1950s and 60s, starring in the iconic television show "I Love Lucy." They were married in real life and had two sons, Desi Arnaz Jr. and Lucie Arnaz.