* Chevy Chase as Clark Griswold
* Beverly D'Angelo as Ellen Griswold
* Juliette Lewis as Margot Griswold
* Johnny Galecki as Rusty Griswold
* Randy Quaid as Cousin Eddie
* Miriam Flynn as Catherine (Cousin Eddie's wife)
* E.G. Daily as Audrey (Cousin Eddie's daughter)
* Nicholas Guest as Todd (Ellen's brother)
* Diane Ladd as Aunt Bethany
* Doris Roberts as Grandma