Here are some women who could be considered contenders, depending on the criteria you use:
* Oprah Winfrey: A media mogul, talk show host, actress, and philanthropist, she's been a dominant force in American media for decades.
* Beyoncé: A globally recognized singer, songwriter, and actress with massive influence in music and pop culture.
* Taylor Swift: A record-breaking singer-songwriter with a devoted global fanbase.
* Emma Watson: An actress known for her role in the "Harry Potter" franchise and her work as a UN Women Goodwill Ambassador.
* Michelle Obama: Former First Lady of the United States, author, and advocate for women's rights.
* Malala Yousafzai: A Pakistani activist for female education, Nobel Prize laureate.
* Greta Thunberg: A young Swedish climate activist who has become a global voice for environmental action.
The answer ultimately depends on your definition of "fame" and what criteria you prioritize (popularity, influence, impact, etc.).