* You lose a guaranteed catch. The Master Ball is the only Poké Ball in the game that has a 100% catch rate, meaning you're guaranteed to catch any Pokémon, no matter how rare or powerful. This can be especially frustrating if you miss a chance to catch a legendary Pokémon or a rare Shiny.
* You can't get another Master Ball. You only receive one Master Ball in the game, so once you use it, that's it.
* You'll likely have to rely on other catching methods. You'll need to use other Poké Balls, along with strategies like weakening the Pokémon or using status effects like Sleep or Paralyze to increase your chances of catching it. This can be more challenging and time-consuming.
However, it's important to note that:
* You can still complete the game. You don't need the Master Ball to beat the game or catch all the Pokémon. You can still catch any Pokémon with enough patience and strategy.
* You can always try again. If you're playing a new game, you can choose to save the Master Ball for a later, more strategic moment.
Ultimately, whether wasting a Master Ball is a big deal depends on your personal playstyle and how much you value catching specific Pokémon. While it's certainly a valuable resource, it's not essential to enjoying the game.