Find out if you have a work that Avon would consider by checking their submission guidelines for the genres and sub-genres they are currently accepting from authors. Some sub-genres include Historical Romance, Paranormal Romance and Inspirational Romance.
Submit your novel-length work of romance or woman's fiction by sending a query to [email protected]. A query is not the manuscript, but a short proposal for your work that is no longer than a page. It should include a brief synopsis, a word count, and is something that will (hopefully) grasp the attention of an editor. Due to the amount of submissions Avon receives, it is helpful to make the purpose of your email as obvious as possible, so put "QUERY" in the subject line of your e-mail.
Wait for a response to your query. This should take six to eight weeks. If they request more material, send it to them. If not, look around for other publishers.