Lead Cast:
- Jessica Alba as Kate
- Timothy Hutton as Ryan
Supporting Cast:
- Jake Muxworthy as Sam
- Wentworth Miller as Jack
- Eddie Cahill as James
- Daphne Zuniga as Alice
- John Savage as Dr. Douglas Branson
- John C. McGinley as Dr. Miles Reed
- Ana Claudia Talancón as Diana
- Ana Gasteyer as Mrs. Hartford
- John Cho as Lee
Uncredited Roles:
- John Malkovich as Narrator
- Ron Leibman as Mr. Hartford