- Andy Griffith played the title character, Sheriff Andy Taylor. Griffith was born in Mount Airy, North Carolina.
- Don Knotts played Deputy Barney Fife. Knotts was born in Morgantown, West Virginia, but he grew up in North Carolina.
- Jim Nabors played Gomer Pyle. Nabors was born in Sylacauga, Alabama, but he moved to North Carolina when he was a child.
- George Lindsey played Goober Pyle. Lindsey was born in Winfield, Alabama, but he also moved to North Carolina when he was a child.
The Andy Griffith Show was set in the fictional town of Mayberry, which was based on Griffith's hometown of Mount Airy. The show was filmed in Raleigh, North Carolina.