* John Candy as James "Jim" Harlow
* Richard Lewis as Seth Maxwell
* Mary Stuart Masterson as Molly
* Ned Beatty as the Reverend
* Danny Glover as Chief Big Bear
* John Cleese as the British Ambassador
* James Coburn as the Duke
* Robert Patrick as the Sheriff
This film also featured a number of supporting actors and actresses, including:
* Timothy Bottoms
* Kevin Nealon
* Jennifer Tilly
* Stephen Tobolowsky
* Harve Presnell
Sadly, John Candy passed away before the film's release, making it his final film.