* Johnny Depp's Involvement: The biggest question mark revolves around Johnny Depp, who played Captain Jack Sparrow. His future with the franchise is uncertain due to legal controversies and public perception. While he has expressed interest in returning, Disney hasn't confirmed his involvement.
* Other Cast Members: Other key cast members, like Orlando Bloom and Keira Knightley, haven't publicly stated whether they would be interested in returning. Their schedules, personal preferences, and the direction of the franchise would all play a role.
* Franchise Future: Disney is currently developing a new Pirates of the Caribbean film with Margot Robbie. This might indicate they are moving on from the original cast and focusing on a fresh direction.
Conclusion:
While some actors might be open to returning, the future of the franchise is unclear, especially with Johnny Depp's situation. Only time will tell if Disney and the actors will find a way to bring the beloved characters back to the big screen.