* Lucille Ball as Mame Dennis
* Bea Arthur as Vera Charles
* Robert Preston as Beauregard Jackson Pickett Burnside
* Bruce Davison as Patrick Dennis
* Jane Connell as Agnes Gooch
* Ralph Bellamy as Mr. Upson
* Sandy Dennis as Mrs. Burnside
* Corynne Charby as Gloria Upson
* Jerry Lester as Ito
This film was a musical adaptation of the original 1966 Broadway production, which starred Angela Lansbury.