Movies:
* Slums of Beverly Hills (1998) - as Rita
* But I'm a Cheerleader (1999) - as Megan
* American Pie (1999) - as Jessica
* Scary Movie (2000) - as Brenda Meeks
* Blade: Trinity (2004) - as "The Night Nurse"
* The Grand (2007) - as Claudine
* All About Steve (2009) - as Harriet
* The Bling Ring (2013) - as Sam
* Antibirth (2016) - as Lou
* The Ballad of Buster Scruggs (2018) - as Alice
* Russian Doll (2019) - as Nadia Vulvokov
* Poker Face (2023) - as Charlie Cale
Television:
* The O.C. (2004) - as Charlotte
* Weeds (2005-2012) - as Norma
* Orange Is the New Black (2013-2019) - as Nicky Nichols
* Russian Doll (2019-2023) - as Nadia Vulvokov (also co-creator, writer, and executive producer)
* Poker Face (2023-present) - as Charlie Cale (also co-creator and executive producer)
Other:
* She has also voiced characters in various animated series and video games.
This list is not exhaustive, but it includes some of Natasha Lyonne's most notable roles. She is a talented and versatile actress, and her career continues to flourish.