* DeForest Kelley played Dr. McCoy in the original Star Trek series (1966-1969) and in the subsequent movies Star Trek: The Motion Picture (1979), Star Trek II: The Wrath of Khan (1982), Star Trek III: The Search for Spock (1984), Star Trek IV: The Voyage Home (1986), and Star Trek VI: The Undiscovered Country (1991).
* Karl Urban played Dr. McCoy in the Star Trek reboot films (2009, 2013, and 2016).