1. Guilt and remorse: After killing Duncan, Macbeth feels overwhelmed with guilt and remorse. He starts to hallucinate, seeing the ghost of Banquo and fearing retribution for his actions. These psychological effects make it difficult for him to cope with his crime and move on.
2. Loss of innocence: Macbeth's murder of Duncan marks a significant turning point in his character. He crosses a moral boundary and loses his innocence. This loss weighs heavily on him, as he feels like he can never go back to the person he was before.
3. Fear of consequences: Macbeth is constantly afraid of the consequences of his crime. He worries about being caught and punished, and he fears the potential for retaliation from others who might seek revenge. This fear keeps him in a state of paranoia and anxiety.
4. Isolation and loneliness: Macbeth's crime isolates him from others. He becomes withdrawn and suspicious, pushing away his wife, Lady Macbeth, and his friends. This isolation exacerbates his guilt and makes it harder for him to deal with his emotions.
5. Ambition and power: Macbeth's initial motivation for killing Duncan is his ambition for power. However, after committing the crime, he finds that the power he gains does not bring him satisfaction or happiness. Instead, it only amplifies his guilt and misery.
Overall, Macbeth's inability to deal with his crime is a result of a combination of psychological torment, moral conflict, fear, and the emptiness that comes from pursuing power at any cost.