* Lois Griffin: The matriarch of the Griffin family, Lois is known for her quick wit, fiery temper, and love for her family (despite their constant misbehavior).
* Tricia Takanawa: Lois's best friend, a somewhat ditzy, yet well-meaning, woman who frequently causes trouble for Lois and Peter.
* Other voices: Borstein also provides voices for various other characters, including the show's narrator, a variety of female characters, and even some male characters.