* Charles Ingalls: The patriarch of the Ingalls family, played by Michael Landon, died in the series finale. He passed away peacefully in his sleep after a long and fulfilling life.
* Caroline Ingalls: Charles' wife, played by Karen Grassle, died in the 1983 TV movie "Little House: The Last Farewell". She passed away after a long battle with illness.
* Albert Ingalls: Charles and Caroline's son, played by Matthew Labyorteaux, died in a tragic accident in Season 8. He was killed while attempting to save a young boy who had fallen into a well.
* Nellie Oleson: The mischievous and often mean-spirited daughter of Nels and Harriet Oleson, played by Alison Arngrim, died in the TV movie "Little House: The Last Farewell". She passed away from complications related to a heart condition.
* Mr. Edwards: The kind and gentle widower who became a close friend to the Ingalls family, played by Victor French, died in Season 7. He passed away after a long illness.
The deaths of these characters were significant events in the series and had a lasting impact on the other characters. While the series was known for its heartwarming moments, it also didn't shy away from depicting the harsh realities of life on the frontier, including death.