Connect the adapter cable. Insert one end into the talk box's input jack. Insert the opposite end into the "Mono Output" of your synthesizer or amplifier. If you are using a guitar, connect a separate cable into the instrument's input jack and the "Output" of the talk box.
Connect the voice tube to the center of the talk box. Take a damp paper towel and wipe the inside and outside of the other end of the tube.
Place the clip at the top of the microphone stand and attach the voice tube. Use rubber bands or similar materials if you do not have a microphone clip.
Adjust the settings. Experiment with the various tone and sound knobs on the talk box until you find a setting that you like.
Activate the talk box by pressing on the stomp button with your foot. Deactivate it by pressing it once more.