Cubase is a sequencer-based program from Steinberg. The program was the first to utilize a grid-interface for arranging sounds, as opposed to a basic list of sound parameters. The grid-interface still prevails today and has the benefit of being highly intuitive for inexperienced users. Cubase contains multiple software instruments powered by digital synthesis, including the "phrase synthesizer."
This is an industry-standard DAW and offers a sophisticated working environment based on the world's most high-end recording studios. Pro Tools is favored by those seeking high quality audio recording, so most people using Pro Tools typically record from external instruments. However, Pro Tools does include a number of software instruments, including Vacuum, a distinctive-sounding monophonic synth.
Mixcraft is a basic program, suitable for less-experienced music makers. It relies heavily on virtual studio technology (VST) plug-ins. This is a universal format that enables third-party programmers to create sound effects for use in a variety of different programs. Mixcraft recommends a range of third-party creators where users can download and install a library of prerecorded sound effects.
This program, made by Apple, is designed to have an intuitive, logical work flow. The majority of the interfaces are arranged as grids, making for easy arrangement and mixing. Logic contains a variety of default sound effects and each are customizable. The ES2 Subtractive Synth has multiple sound parameters, meaning slight tweaks to each can create a diverse range of sound effects that don't appear to be from the instrument. Another distinctive advantage of Logic is that you can assign the computer keyboard as the primary input device for MIDI, removing the need to use an external hardware controller.
Garage Band is also made by Apple and comes free with most Mac computers. It is effectively a ligh" version of Logic. One of the advantages of this program is that is has basic functionality but a range of sound effects similar to more professional workstations.