Connect the outputs of your audio interface or mixer to the inputs of your equalizer.
Set the outputs on the equalizer to the parts of the frequency range that you desire. You may want to have more than one amplifier powering the same wide portion of the frequency spectrum, or to split the signal into a low, middle and high, and power each portion separately. You may also choose to group the mid and high ranges together, sending both outputs to one amplifier then to speakers, and send the low range to a separate amplifier then into the subwoofers. This will depend on your personal preference based upon the space and equipment you are using.
Connect the outputs on the equalizer to the inputs of the desired amplifiers. How you choose to group the outputs depends on the number of amplifiers and the type of speakers. Be sure to send the low range outputs to a separate amplifier, since you will want to connect those to the subwoofers.
Set any amplifiers powering a mono signal to bridge mode. This will be found on the back of your amplifier.
Connect the amplifier outputs to the speakers corresponding with each part of the frequency spectrum that you are amplifying.