Open Ableton Live. Click the "Plug-in Devices" button, which looks like an electrical plug, on the left-hand side of the screen. Scroll down to SampleTank.
Click and drag SampleTank from the Plug-in Devices panel to a MIDI track in the main window. Click on the arrow next to one of the instrument categories in the "Browser" window to expand it. Double-click an instrument to load it.
Click the entry for "Part 2" in the "Instrument" window to load another instrument sound, if desired. Double-click an instrument in the "Browser" window to load it into SampleTalk. If you want the two samples to play simultaneously, change the "CH" setting for "Part 2" to "1." Leave this setting as-is if you want to control the different samples using separate MIDI tracks. Add any other samples you want to use in the same way.
Alter the synthesizer's settings as desired. You can change the envelope settings, LFO modulations and filter settings for each sample individually. Adjust the volume settings for each sample until they blend together harmoniously. To solo a sample, click the "S" button next to it. To temporarily remove a sample from the mix, click the "M" button.
Add effects to your sound using the "Effects" section just above the on-screen keyboard. SampleTank includes built-in reverb, chorus, delay and compressor effects. Using these effects, rather than adding third-party effects to the track, can help reduce the load on your computer's processor.
Click the "Record" button at the bottom of the SampleTank track to arm it for recording. Play your MIDI keyboard, or add a MIDI clip to the Ableton MIDI track and click "Play." Adjust the settings in SampleTank as needed until you've perfected your new sound. Save your sound as a preset by clicking the "Save As" button at the top of SampleTank and saving it to your hard drive.