Ensure that your VST (Virtual Studio Technology) host can see "RealStrat." Check on the menu in your specific host program to see if "RealStrat" is there. Go to the "RealStrat" installation folder and find "RealStrat.dll" if the VST host can't see "RealStrat." Copy this file and paste it directly into the VST plugin directory.
Install your chosen amplifier simulation program. Ensure that this is visible to your VST host in the same way. After this has been installed, click on the "Instruments" window in your VST host program. Choose "RealStrat" from the "No Instrument" section to load the program up. Click the "Edit" button beside the "RealStrat" box to open up the program window.
Choose your amplifier simulator as the output source for the MIDI (Musical Instrument Digital Interface) track. Click "Edit" if you wish to alter the values or change the distortion mode. On "Amplitube 2 DUO," use the "Overdrive" stomp box and turn the "Drive" and "Tone" knobs to your desired level.
Select "Chords" on "RealStrat" if you wish to strum chords through distortion. Alternatively, select "Solo" to play individual notes through your distortion program. Look below the guitar's neck on the program's main interface to see these options. You can also choose other modes such as "Bass and Chord" or "Bass and Pick" to play the guitar differently.
Use the "Main Zone" of your MIDI keyboard (or the one displayed on-screen in "RealStrat") to play notes through distortion. In chord mode, you can repeat the chord you previously played in the "Main Zone" by playing in the "Repeat Zone." The "Main Zone" stretches from E1 to B4 on the MIDI keyboard, and anything outside this is the "Repeat Zone." Play C, E and G in the "Repeat Zone" to up-stroke and D, F and A to play a down-stroke. Use the flats to play muted strums.