The story takes place in the fictional region of Dartmoor in Devon, England, specifically focusing on the locations of:
* Baskerville Hall: The ancestral home of the Baskerville family.
* Grimpen Mire: A treacherous bogland where the legendary hound is said to roam.
* The Manor House: Where Sir Henry Baskerville stays.
* The village of "The Village" (unspecified name): The nearby community where the local residents live.
* The railway station: How Sir Henry arrives at Baskerville Hall.
There is no mention of any place called Coombe Tracey in the novel.