Owen Wilson provides the voice of Lightning McQueen, a hotshot rookie race car who only wants to win at all costs. He imagines himself as having fame and fortune and is determined to win. When he breaks down in the small town of Radiator Springs, he learns a valuable life lesson.
The voice of Mater, a little tow truck in Radiator Springs, is provided by Larry the Cable Guy. Mater is the good ole boy type and is an eternal optimist. He befriends McQueen and gives him a lot of friendly advice.
Sally is a 2002 Porsche 911 from California who left the big city life for the laid-back town of Radiator Springs. She now serves as the attorney for the small town and wants to preserve its history. Bonnie Hunt is the voice of Sally.
A 1970 Plymouth Superbird is a racing legend named Strip Weathers, voiced by Richard Petty. This hometown guy has been successful at winning many trophies. He understands what it means to be on top and is now ready to retire. Mrs. The King is a 1974 Chrysler Town and Country station wagon voiced by Petty's real life wife, Lynda Petty.
Joe Ranft, one of the directors of the film, provides his voice for Red, a 1960's fire truck. Red is characterized as being sensitive and cries when McQueen destroys some flowers.
A 1951 Hudson Hornet named Doc Hudson is voiced by Paul Newman. Doc is a country doctor who teaches McQueen a valuable life lesson.
Michael Schumacher lends his own voice to a 2006 Ferrari F430. He appears at the end of the movie to buy tires from Luigi and states that he was referred by McQueen.
California governor Arnold Schwarzenegger provides the voice for a Hummer. He is a minor character with only one line.
Ramone is a 1959 Chevrolete Impala Lowrider. He owns a paint shop in Radiator Springs. He is married to Flo, a mixture of a 1951 Buick LeSabre and a Chrysler Dart. She owns the V8 Cafe.