Live-Action:
* The Adventures of Rocky & Bullwinkle (2000) - as Carlos
* The Big Bounce (2004) - as Oscar
* Spare Parts (2015) - as Mr. Garza
* A Lot Like Love (2005) - as Larry
* Beverly Hills Chihuahua (2008) - as Papi
* Beverly Hills Chihuahua 2 (2011) - as Papi
* Beverly Hills Chihuahua 3: Viva La Fiesta! (2012) - as Papi
* The Smurfs (2011) - as Grouchy Smurf (voice)
* Rio 2 (2014) - as Rafael (voice)
* The Three Amigos (2016) - as Tony
* The Valet (2022) - as Armando
Animation:
* The Smurfs (2011) - as Grouchy Smurf (voice)
* Rio 2 (2014) - as Rafael (voice)
* The Adventures of Puss in Boots (2011-2012) - as Humpty Dumpty (voice)
* The Cleveland Show (2009-2013) - as himself (voice)
* The Simpsons (2016) - as himself (voice)
Other:
* George Lopez: America's Mexican (2006) - as himself (stand-up comedy special)
* George Lopez: Tall, Dark & Chicano (2012) - as himself (stand-up comedy special)
* Lopez (2007-2011) - as George Lopez (TV series)
This is just a sample, and he has starred in many other films and television shows! You can find a more comprehensive list on his IMDb page.