- The Man Who Shot Liberty Valance (1962) - as Hallie Stoddard
- The Big Red (1965) - as Martha McKenna
- Follow Me, Boys! (1966) - as Kate Dunnigan
- The Russians Are Coming, the Russians Are Coming (1966) - as Justine Melville
- Once Upon a Time in the West (1968) - as Jill McBain
- The Undefeated (1969) - as Charlotte Langdon
- The Great White Hope (1970) - as Eleanor Backman
- The Andromeda Strain (1971) - as Dr. Mark Hall
- Slaughterhouse-Five (1972) - as Mary O'Hare
- The Sting (1973) - as Loretta Salino
- The Great Gatsby (1974) - as Myrtle Wilson
- Rollerball (1975) - as Ella James
- King Kong (1976) - as Dwan
- Gray Lady Down (1978) - as Commander Roskam
- The Shining (1980) - as Wendy Torrance
- Out of Africa (1985) - as Felicity
- Ghostbusters (1984) - as Dana Barrett
- The Presidio (1988) - as Donna Caldwell
- Driving Miss Daisy (1989) - as Daisy Werthan
- Dick Tracy (1990) - as Breathless Mahoney
- JFK (1991) - as Priscilla Johnson McRaven
- Batman Returns (1992) - as Selina Kyle / Catwoman
- The Pelican Brief (1993) - as Darby Shaw
- In the Valley of Elah (2007) - as Joan Deerfield
Television series:
- Naked City (1958-1963) - as various characters
- Route 66 (1961-1964) - as various characters
- The Nurses (1962-1965) - as various characters
- Dr. Kildare (1964-1966) - as various characters
- The Man from U.N.C.L.E. (1965-1968) - as various characters
- Mission: Impossible (1966-1973) - as various characters
- The Fugitive (1966-1967) - as various characters
- The Invaders (1967-1968) - as various characters
- Star Trek: The Original Series (1967-1969) - as Nyota Uhura
- Columbo (1971-1972) - as Beth Chadwick
- Murder, She Wrote (1984-1996) - as Jessica Fletcher