- 1992: Best New Artist
- 1994: Best Rap Album (Music from the Motion Picture: Menace II Society)
- 1996: Best Rap Album (All Eyez on Me)
- 1997: Best Rap Album (The Eazy-E Story)
- 1998: Best Rap Performance by a Duo or Group (I Got 5 on It)
American Music Awards:
- 1994: Favorite Rap/Hip-Hop Artist
- 1994: Favorite Rap/Hip-Hop Album (Music from the Motion Picture: Menace II Society)
- 1995: Favorite Rap/Hip-Hop Artist
- 1995: Favorite Rap/Hip-Hop Album (All Eyez on Me)
- 1996: Favorite Rap/Hip-Hop Artist
- 1996: Favorite Rap/Hip-Hop Album (The Eazy-E Story)
- 1997: Favorite Rap/Hip-Hop Artist
- 1997: Favorite Rap/Hip-Hop Album (Death Row Greatest Hits)
- 1998: Favorite Rap/Hip-Hop Artist
- 1998: Favorite Rap/Hip-Hop Album (No Way Out)
MTV Video Music Awards:
- 1993: Best Rap Video (Nuthin' But a 'G' Thang)
- 1994: Best Rap Video (California Love)
- 1995: Best Rap Video (California Love Remix)
- 1995: Best Video from a Film (I Ain't Mad at Cha)
Brit Awards:
- 1995: International Male Solo Artist
- 1995: International Breakthrough Act
ECHO Awards:
- 1995: Best International Hip-Hop/R&B Artist
BET Awards:
- 1998: Lifetime Achievement Award
- 1999: Best Group
- 2002: Video of the Year (Beautiful)
Soul Train Awards:
- 1993: Best Rap Album (Music from the Motion Picture: Menace II Society)
- 1994: Best R&B/Soul or Rap New Artist
- 1995: Best Rap Album (All Eyez on Me)
- 1995: Best Rap Single (California Love)
- 1996: Best Rap Album (The Eazy-E Story)
- 1998: Aretha Franklin Award