American Music Awards
- Favorite Rap/Hip-Hop Album: "Planet Pit" (2012)
Billboard Latin Music Awards
- Top Latin Album of the Year: "Dale" (2007)
- Hot Latin Song of the Year: "I Know You Want Me (Calle Ocho)" (2009)
- Top Latin Album of the Year: "Rebelution" (2010)
- Top Latin Album of the Year: "Global Warming: Meltdown" (2013)
- Latin Rhythm Album of the Year: "Dale" (2007)
- Latin Rhythm Album of the Year: "The Boatlift" (2007)
- Latin Rhythm Album of the Year: "Planet Pit" (2012)
- Latin Rhythm Song of the Year: "Calle Ocho (I Know You Want Me)" (2009)
- Latin Rhythm Song of the Year: "Bon Bon" (with T-Pain) (2010)
- Latin Rhythm Song of the Year: "Rain Over Me" (with Marc Anthony) (2012)
BMI Latin Awards
- Song of the Year: "I Know You Want Me (Calle Ocho)" (2009)
- Songwriter of the Year: Armando C. Perez (2013)
Grammy Awards
- Latin Pop Album: "El Mariel" (2008)
- Best Latin Urban Album: "Global Warming: Meltdown" (2013)
Latin Grammy Awards
- Best Contemporary Tropical Album: "Dale" (2007)
- Record of the Year: "I Know You Want Me (Calle Ocho)" (2009)
- Song of the Year: "I Know You Want Me (Calle Ocho)" (2009)
MTV Video Music Awards
- Best Collaboration: "Give Me Everything" (with Ne-Yo, Afrojack, & Nayer) (2012)
People's Choice Awards
- Favorite Hip-Hop Song: "Fireball" (2014)