- A rejection of prejudice and discrimination. Twain's novel powerfully portrays the racism and discrimination that existed in the antebellum South, and he hoped that his readers would be inspired to challenge these prejudices and work towards a more just and egalitarian society.
- A greater appreciation for the inherent worth of all people. Twain's novel shows that even the most marginalized and downtrodden people have value and deserve to be treated with respect. He hoped that his readers would come to see the humanity in all people, regardless of their race, class, or social status.
- A stronger sense of compassion and empathy. Twain's novel shows the devastating effects of cruelty and indifference, and he hoped that his readers would be moved to be more compassionate and empathetic towards others. He believed that a more compassionate society would be a more just and peaceful society.
- A greater love for freedom and independence. Twain's novel celebrates the freedom and independence of the human spirit, and he hoped that his readers would be inspired to fight for their own freedom and independence. He believed that a free and independent people would be a more prosperous and happy people.
These were some of the specific changes in human nature that Mark Twain hoped his satire would encourage. He believed that his novel could help to create a more just, egalitarian, and compassionate society.