Decide on the scope of your piece. If you are drawing only a head, then center your drawing. If you are drawing an entire body or partial body with the head, then you will need to realign the head accordingly.
Draw a simple circle for the wolf's head. This should be one-fourth the size of the entire body (if you are drawing one). If you are drawing only a head, you can fill your page with the circle.
Attach a cylindrical shape to the side of your circle to begin the muzzle. As you begin detail work on the mouth and nose of your wolf, keep in mind that you can add dimension by observing the shadows and light around the area, shading it appropriately and giving the muzzle depth with different layers to the initial cylinder shape.
Add upside-down triangles in varying length to the undersides of the wolf's mouth. These teeth should be pointy, with negative space left in the middle to give a gleaming white appearance. You can shade the side of each as the light hits them from one direction to add drama.
Concentrate on your wolf's eyes by shading them dark in the pupils. Leave a pop of white in the upper inside corner to give a reflection of light common to anime characters.
Draw a lot of exaggerated hair in spiky chunks low around the forehead, arching back across your wolf's neck and upper back. This is not necessarily realistic, but is very widely used in anime to give wolves intimidating and ethereal appearances.
Add standing, pointed ears to the side of your circle. If the wolf's head is turned, the ear furthest away should be one-third smaller than the one closest to you. You can also add hairs or dark shading to the center of each ear to enhance detail.
Finish your wolf's head with whiskers, a scar or patches of color.