Runbeck's work is often autobiographical, and it explores themes of family, loss, and the search for identity. She has been praised for her ability to create vivid and memorable characters and for her use of language. Her work has been compared to that of Flannery O'Connor and Carson McCullers.
Runbeck's novels include "The Tree That Bears Fruit" (1983), "The Secret Life of Bees" (1992), "We Are All Together Now" (1994), and "The Far Away Brothers" (1996). Her short-story collections include "The Best Little Girl in the Whole World" (1988) and "Some Things to Be Happy About" (2001).
Runbeck's work has been translated into more than 30 languages, and she has received numerous awards, including the National Book Critics Circle Award for Fiction and the PEN/Faulkner Award for Fiction. She died of breast cancer in 1990, at the age of 39.