- Fernando Poe Jr. as Kumander .45
- Gloria Diaz as Lisa
- Dante Varona as Col. Carlos Ortega
- Vic Varrion as Maj. Ramon Delgado
- Bembol Roco as Lt. Benjie Ramos
- Johnny Delgado as Sgt. Mario Fernandez
- Eddie Garcia as Gen. Victor Delgado
- Paquito Diaz as Chief Inspector Antonio Diaz
- Max Alvarado as Dr. Salvador Santos
- Dindo Arroyo as Capt. Dante Rivera
- Celia Rodriguez as Aling Rosing
- Chanda Romero as Kumander .45's Mother
- Perla Bautista as Kumander .45's Wife
- Niño Muhlach as Kumander .45's Son
- Maria Theresa Carlson as Kumander .45's Daughter
- Romy Diaz as the Secretary