- Janet Gaynor as Anni Rembach
- Robert Donat as Stefan Brand
- Lionel Barrymore as Carl Bergson
- Murray Kinnell as Dr. Frederick Mollring
- Ernest Cossart as Dr. Otto Krahmner
- Virginia Weidler as Hildegarde 'Hedy' Brand
- Minor Watson as Dr. Emil Schmidt
- Mary Nash as Mrs. Rembach
- Esther Dale as Baroness Gertrude Von Stoger