- Richard Burgi as Detective Lee Scanlon
- James Marsters as Spike
- Christian Kane as Lindsey McDonald
- Amy Acker as Winifred Burkle
- J. August Richards as Charles Gunn
- Alexis Denisof as Wesley Wyndam-Pryce
- Mercedes McNab as Harmony Kendall
- Juliet Landau as Drusilla
- Sam Spruell as Dr. Sparrow