* Nick Nolte as John, the mysterious stranger
* James Woods as Clem, the town's doctor
* Daryl Hannah as Clara
* Peter Coyote as Father Lucian
* Susan Sarandon as Rachel
* Tom Waits as George
* Mike Farrell as Henry
* Jon Voight as Howard
* Timothy Hutton as Joe
* Jamie Lee Curtis as Ruby
* Kevin Spacey as William
* Danny Glover as Jake
* Ethan Hawke as Adam
* Lewis Smith as Daniel
* Paul Bettany as John
* David Strathairn as The Preacher
* Laura Linney as Mary
* Patricia Clarkson as Martha
* Kieran Culkin as David
* Piper Perabo as Helen
This film boasts a truly impressive ensemble cast, bringing together renowned actors from various genres.