* Joel McCrea as Captain Tom McKay
* Yvonne De Carlo as Nanette
* John Derek as Lieutenant George Eaton
* Richard Anderson as Sergeant Henry King
* Michael Ansara as Chief Black Hawk
* Henry Brandon as Major William Benton
* John Lupton as Lieutenant Jim Harris
* Harry Carey Jr. as Sergeant O'Brien
* James Coburn as Private "Hawkeye" Jackson
* Lee Van Cleef as Corporal John "Dutch" Peters
This cast is known for their roles in various Western films and other genres, making "Fort Massacre" an interesting and memorable film with a strong ensemble.