* Katherine Heigl as Jane Nichols
* James Marsden as Kevin Doyle
* Malin Åkerman as Tess Nichols
* Ed Burns as George
* Judy Greer as Casey
* Melora Hardin as Maureen Nichols
* Bryan Greenberg as Greg
* Michael Rady as Michael O'Neil
* Candice Bergen as George's Mother
Supporting Cast
* David Castro as Edward
* Krysten Ritter as Gina
* Mary Alice as Jane's Grandmother
* Tyra Ferrell as Nurse