* The X-Files (1994-2002) as Det. Dana Scully
* The Lone Gunmen (2001-2002) as Det. Dana Scully
* Millennium (1996-1999) as Det. Dana Scully
* Fringe (2008-2013) as Det. Olivia Dunham
* Taken (2002) as Kate Ryan
* The Practice (2000-2001) as Kate Ryan
* NYPD Blue (1993-2005) as Det. Jane Timoney
* CSI: Miami (2002-2012) as Det. Calleigh Duquesne
* Without a Trace (2002-2009) as Det. Samantha Spade
* Numb3rs (2005-2010) as Dr. Charlie Eppes
* Monk (2002-2009) as Sharona Fleming
* Psych (2006-2014) as Det. Juliet O'Hara
* Burn Notice (2007-2013) as Sam Axe
* Leverage (2008-2012) as Sophie Devereaux
* White Collar (2009-2014) as Neal Caffrey
* Covert Affairs (2010-2014) as Annie Walker
* The Americans (2013-2018) as Elizabeth Jennings
* The Blacklist (2013-2019) as Elizabeth Keen
* The Catch (2016-2017) as Alice Vaughan
* Quantico (2015-2018) as Alex Parrish
Film
* The X-Files: Fight the Future (1998) as Det. Dana Scully
* The X-Files: I Want to Believe (2008) as Det. Dana Scully
* Alien: Resurrection (1997) as Lt. Ellen Ripley
* Independence Day (1996) as Capt. Steven Hiller
* The Net (1995) as Angela Bennett
* A Time to Kill (1996) as Ellen Roark
* The Negotiator (1998) as Christy Sabich
* Deep Blue Sea (1999) as Dr. Susan McAlester
* Vertical Limit (2000) as Annie Garrett
* Frequency (2000) as Julia Sullivan
* The Gift (2000) as Katie Holmes
* The Bourne Identity (2002) as Marie Kreutz
* The Sum of All Fears (2002) as Dr. Catherine Muller
* The Bourne Supremacy (2004) as Marie Kreutz
* The Bourne Ultimatum (2007) as Marie Kreutz
* Evan Almighty (2007) as Joan Baxter
* The Invasion (2007) as Carol Bennell
* The Ugly Truth (2009) as Abby Richter
* Love Happens (2009) as Dr. Eloise Chance
* The Conspirator (2010) as Mary Surratt
* The Adjustment Bureau (2011) as Elise Sellas
* Margin Call (2011) as Sarah Robertson
* Tower Heist (2011) as FBI Agent Claire Denham
* Zero Dark Thirty (2012) as Maya
* The Fifth Estate (2013) as Rebecca MacKinnon
* Captain Phillips (2013) as Irene Phillips
* Big Eyes (2014) as Margaret Keane
* Foxcatcher (2014) as Nancy Schultz
* Joy (2015) as Trudy Campanello
* Collateral Beauty (2016) as Claire Wilson
* Hidden Figures (2016) as Vivian Mitchell
* The Shape of Water (2017) as Zelda Fuller
* Lady Bird (2017) as Marion McPherson
* Three Billboards Outside Ebbing, Missouri (2017) as Mildred Hayes
* A Quiet Place (2018) as Evelyn Abbott
* A Quiet Place Part II (2020) as Evelyn Abbott
* Don't Look Up (2021) as Jane Orlean