* Christopher Connelly as Zebulon Pike
* Rod Taylor as Meriwether Lewis
* William Atherton as William Clark
* Nick Ramus as Jedediah Smith
* James Callahan as Davy Crockett
* Gregg Palmer as Jim Bridger
* John Dehner as Manuel Lisa
* Richard Boone as Daniel Boone
* Robert Donner as Thomas Jefferson
* John Doucette as Andrew Henry
* James Griffith as John Colter
* Don Keefer as John C. Frémont
* Elisha Cook, Jr. as Jim Baker
* Robert F. Lyons as Hugh Glass
* William Bryant as Peter Skene Ogden
* Robert Ginty as Kit's young helper