* Feroze Khan as Asfandyar "Zaroon" Junaid
* Sanam Baloch as Kashaf Murtaza
* Adeel Hussain as Osman "Ozzie" Khalil
* Saba Hameed as Zaroon's mother
* Ismat Zaidi as Kashaf's mother
* Qavi Khan as Kashaf's father
* Humayun Ashraf as Kashaf's brother
* Shaheen Khan as Zaroon's aunt
The series also featured many other supporting actors, including:
* Farhan Ali Agha
* Asif Raza Mir
* Nausheen Shah
* Behroze Sabzwari
* Nida Mumtaz
* Yasir Mazhar
Zindagi Gulzar Hai was a hugely popular Pakistani drama, known for its excellent cast performances and its compelling storyline.