Gamora is a skilled fighter who has been trained in martial arts and weaponry since childhood. She is also possesses super strength, speed and durability as well as the ability to manipulate gravity which allows her to fly.
In terms of physical strength and agility, Spider-Man and Gamora are relatively equal. However, Gamora has more combat experience and is more proficient in using a variety of weapons and tactics. Additionally, her ability to manipulate gravity could give her an advantage in a fight.
Ultimately, the winner of a fight between Spider-Man and Gamora would likely depend on the specific circumstances of the fight and how each fighter used their abilities. However, based on their powers and abilities, Gamora would likely have the edge over Spider-Man in most scenarios.