* Erica Durance as Lois Lane
* Cassidy Freeman as Tess Mercer
* Alessandro Juliani as Emil Hamilton
* Laura Vandervoort as Kara Kent / Supergirl
* Sam Witwer as Davis Bloome / Doomsday
* Michael Rosenbaum as Lex Luthor
* Terrance Stamp as Jor-El
* Allison Mack as Chloe Sullivan
* Justin Hartley as Oliver Queen / Green Arrow