Action/Adventure:
* Danny Ocean in the "Ocean's Eleven" franchise (2001-2007, 2018)
* Jack Sheppard in "Solaris" (2002)
* Captain William Cage in "Edge of Tomorrow" (2014)
* Augustus "Augie" Fairbanks in "The Monuments Men" (2014)
Comedy:
* Ryan Bingham in "Up in the Air" (2009)
* Barry Egan in "Confessions of a Dangerous Mind" (2002)
* George Clooney in "Intolerable Cruelty" (2003)
* Matt King in "The Descendants" (2011)
* John Gage in "Hail, Caesar!" (2016)
Drama:
* Dr. Ross "Doc" Ross in "ER" (1994-1999)
* Jack Foley in "Michael Clayton" (2007)
* Frank Walker in "The American" (2010)
* George Clooney in "Good Night, and Good Luck." (2005)
* Thad Castle in "The Tender Bar" (2021)
Sci-Fi:
* Tom Reed in "Gravity" (2013)
* Dr. Ryan Stone in "Solaris" (2002)
Other:
* Batman in "Batman & Robin" (1997)
* Lee Gates in "The Ides of March" (2011)
Note: This list is not exhaustive, and George Clooney has played many other memorable characters throughout his career. It's a great exercise to watch some of his movies and enjoy his versatility as an actor!