After Scarface, Santana continued his acting career with television appearances in series such as Miami Vice, The A-Team, and Baywatch. He also appeared in films such as Running Scared (1986), Predator 2 (1990), and White Sands (1992).
In the 1990s, Santana's career slowed down, and he began working as a real estate agent in Miami, Florida. He has also done some voice acting work for video games and animated series.
In 2019, Santana appeared as himself in the documentary Scarface: The World Is Yours, which chronicled the making of the film and its legacy.
Santana is married with two children and resides in Miami. He continues to act occasionally and is also a motivational speaker.