* Land Area: Approximately 160 acres are dedicated to the theme park itself.
* Total Area: When you consider all the areas including backstage, support facilities, and other non-guest areas, the total size is much larger, but this information is not publicly available.
To give you a better idea of scale, consider that the Magic Kingdom is slightly larger at 107 acres.
So, Disney's Hollywood Studios is a substantial theme park, but slightly smaller than Magic Kingdom.