* Miss Hannigan: Annie's cruel and neglectful orphanage caretaker.
* The other orphans: Annie has several friends at the orphanage, including Pepper, Duffy, and Molly. They form a strong bond with each other.
* Warbucks: The wealthy businessman who takes Annie into his home. He becomes a father figure to her.
* Grace Farrell: Warbucks' secretary who becomes Annie's confidante and friend.
* Sandy: Annie's loyal dog, who becomes a symbol of hope and companionship.
While Annie doesn't have a biological family, she finds love and support in the people she encounters throughout her journey.