* Julianne Moore as Dr. Sarah Harding
* Vince Vaughn as Nick Van Owen
* Pete Postlethwaite as Roland Tembo
* Richard Schiff as Eddie Carr
* Cameron Thor as Lewis Dodgson
* Vanessa Lee Chester as Kelly Curtis
* Arliss Howard as Peter Ludlow
* Joseph Mazzello as Tim Murphy
* Ariana Richards as Lex Murphy
* James Cromwell as Dr. John Hammond
* Bob Peck as Robert Muldoon
* Samuel L. Jackson as Ray Arnold
* Wayne Knight as Dennis Nedry