* Luther Waffles: A 12-year-old boy who lives in the town of Hickory and becomes Zeke's best friend. He is a bit of a troublemaker, but he is also very loyal and kind-hearted.
* Ginger Falcone: Zeke's 15-year-old sister, who is intelligent, witty, and fiercely protective of her brothers.
* Layla: Luther's crush and Zeke's love interest. She is the popular and intelligent girl in their class.
* C.J.: Luther's best friend who often gets him in trouble.
* Kojo: Zeke's friend and the owner of a local comic shop. He is wise, kind, and supportive of Zeke.
* Mr. Theodore "Ted" Falcone: Zeke and Ginger's father, a former lawyer and now the town's new sheriff. He is strict but loving, and he is doing his best to raise his children after their mother's death.
* Olivia: Zeke's crush and Luther's love interest, she is the town's resident psychic who helps the boys solve mysteries.
* Munch: The school bully and Zeke's main antagonist, who often tries to pick on Luther.